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Saturday, March 12, 2016

Answers to FAQ's About Fish Oil for ADHD

Many people with ADHD take omega 3 fatty acids  or "omega 3's" for their symptoms, but a quick tour down the grocery aisle (or the internet) reveals a dizzying number of options all touting a number of characteristics which you probably have never considered.  Isn't fish oil, well... fish oil?  This article will help you understand the characteristics which are important in selecting an omega 3 supplement to fit your needs, as well as the basics of dosage and side effects.


Is the source of the omega 3 fatty acids important?   The major omega 3 fatty acids used by the brain are DHA and EPA.  The body can also make DHA and EPA from ALA (made by plants), but you must consume a much higher amount of ALA to get what you need in DHA and EPA.  Usually humans can only get the amounts of DHA and EPA needed to treat ADHD from algae or sea animals such as fatty fish, seals, and krill.  Other foods, like eggs, meat, and cereals may contain some omega 3’s but not enough to be important supplements.

Most omega 3’s are regulated as supplements and do not receive the same scrutiny for effectiveness that drugs do from the FDA.  There are some prescription omega 3 fatty acids that have been available as drugs but not for ADHD.  There is also a prescription medical food for ADHD containing omega 3 fatty acids which does not receive the same level of regulation as a drug would.

Why are mercury, PCBs, and dioxin critical?
Fatty fish accumulate toxins such as mercury, PCBs, and dioxins in their oil/fat.  Mercury poisons the nervous system.  PCBs and dioxins have been implicated in possibly causing diabetes, thyroid disorders, and cancer.  People taking fish oil should check the label to make sure their supplement is certified free of mercury, PCBs and dioxins because larger doses of fish oil over longer periods of time are needed to treat ADHD than other common disorders.

Is EPA or DHA more important?  The bottom line is that no one knows for sure right now. Different studies give conflicting answers and high quality studies haven’t been designed to answer this question.

Is omega 6 necessary?   Experts are divided because small trials of omega 3s combined with omega 6s have shown effectiveness in treating ADHD symptoms, which is not what one would expect since omega 6's opposite effects to omega 3's studies done investigating heart health.

What doses should be used?  Experts generally recommend a target dose of 300-600mg omega 3/30-60mg omega 6 daily for children, and 1-3 g of DHA for adults.    Most authorities recommend starting at a lower dose and increasing gradually to the target dose in order to avoid upset stomach and diarrhea.  The dose is high compared to the dose sizes available.  Be sure to take the number and size of pills into account when you purchase a fish oil supplement.

When will I see an effect?  Most clinical trials that have demonstrated an effect have run for 8-12 weeks or longer.  Experts recommend at least a 2 to 3 month trial at an adequate dose. If you haven’t seen an effect at that time and your diet isn’t deficient in omega 3 fatty acids, you can stop the supplement.

What are the side effects of omega 3 fatty acid supplements?  The vast majority of patients notice nothing. The most common side effects, especially at higher doses,  include a fishy aftertaste/burps and diarrhea/stomach upset.  Less common side effects include raising LDL (aka "bad") cholesterol (though without an increase in heart attacks), and prolonged bleeding.  The largest problem is that fish oil can taste fishy, a flavor not all patients find appetizing.

Are there any other things I should be aware of?   Some supplements may contain “inactive” ingredients which may worsen symptoms of ADHD.  For example, some may contain gluten, artificial flavoring, or glucose (sugar).  Check the label to be sure.

Gummies and soft gels can become stuck together in summer heat, leaving you with a blob of pills that have to picked apart.  If you are ordering online, this can be a particular issue and it is best to order a good supply before summer gets too warm, in order to avoid this inconvenience.

Why can’t I just eat more fish?  Some recent studies conclude that only people deficient in omega 3 fatty acids benefit from supplementation.  This may mean that getting omega 3’s from your diet may be equally beneficial, however it does mean that you eat a lot of fish.  It would probably be best to supplement if your diet contains less fish than 2 servings a week.

References:
Bloch, M. H., and A. Qawasmi. "Omega-3 Fatty Acid Supplementation for the Treatment of Children with Attention-deficit/hyperactivity Disorder Symptomatology: Systematic Review and Meta-analysis." Journal of the American Academy of Child and Adolescent Psychiatry 50.10 (2011): 991-1000. Print.

Cooper, R. E., C. Tye, J. Kuntsi, E. Vassos, and P. Asherson. "Omega-3 Polyunsaturated Fatty Acid Supplementation and Cognition: A Systematic Review and Meta-analysis." Journal of Psychopharmacology29.7 (2015): 753-63. Web.

Covington, Maggie B. "Omega-3 Fatty Acids." American Family Physician 70.1 (2004): 133-40. Print.

Millichap, J. G., and Michelle M. Yee. "The Diet Factor in Attention-Deficit/Hyperactivity Disorder." Pediatrics 129.2 (2012): 330-37. Print.

Sinn, Natalie, Catherine Milte, and Peter R. C. Howe. "Oiling the Brain: A Review of Randomized Controlled Trials of Omega-3 Fatty Acids in Psychopathology across the Lifespan." Nutrients 2.2 (2010): 128-70. Print.



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